Cardiovascular drugs that increase the risk of new-onset diabetes
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چکیده
منابع مشابه
When does new onset diabetes resulting from antihypertensive therapy increase cardiovascular risk.
The report in this issue of Hypertension by Verdecchia et al,1 a prospective study in a relatively large group of patients with uncomplicated essential hypertension, demonstrated two important findings. First, baseline level of plasma glucose and use of diuretics after a median follow-up of 6 years were independent predictors for development of new onset diabetes. Second, they observed that the...
متن کاملNew-onset diabetes and risk of all-cause and cardiovascular mortality: the Cardiovascular Health Study.
OBJECTIVE Cardiovascular risk associated with new-onset diabetes is not well characterized. We hypothesized that risk of all-cause and cardiovascular mortality would be similar among participants with and without new-onset diabetes in the first years of follow-up and rise over time for new-onset diabetes. RESEARCH DESIGN AND METHODS The Cardiovascular Health Study (CHS) is a longitudinal stud...
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The main etiology for mortality and a great percentage of morbidity in patients with diabetes mellitus is atherosclerosis. The pathogenesis of cardiovascular disease (CVD) in diabetes is multifactorial and can be affected by metabolic and other factors. A hypothesis for the initial lesion of atherosclerosis is endothelial dysfunction, defined pragmatically as changes in the concentration of the...
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The Food and Drug Administration issued guidance for evaluating the cardiovascular risk of new diabetes mellitus drugs in 2008. Accumulating evidence from several completed trials conducted within this framework raises questions as to whether requiring safety outcome studies for all new diabetes mellitus therapies remains justified. Given the burden of cardiovascular disease in patients with di...
متن کاملThe comparative risk of new-onset diabetes after prescription of drugs for cardiovascular risk prevention in primary care: a national cohort study
OBJECTIVE Recent studies suggest that statins increase the risk of subsequent diabetes with a clear dose response effect. However, patients prescribed statins have a higher background risk of diabetes. This national cohort study aims to provide an estimate of the comparative risks for subsequent development of new-onset diabetes in adults prescribed statins and in those with an already higher b...
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ژورنال
عنوان ژورنال: American Heart Journal
سال: 2014
ISSN: 0002-8703
DOI: 10.1016/j.ahj.2013.12.025